Rheumatoid arthritis, Polyarticular-course juvenile rheumatoid arthritis (JRA), Psoriasis, Certain types of cancers
Body Site:
non-application
Prescription Only:
yes
Steroid Free:
unavailable
Tar Free:
yes
Ingredients:Each tablet contains methotrexate sodium in an amount equivalent to the labeled amount of methotrexate,
and contains the following inactive ingredients: anhydrous lactose, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, pregelatinized starch, sodium carbonate monohydrate, talc and titanium dioxide.
The 5 mg also contains: D&C yellow no. 10 aluminum lake, FD&C blue no. 1 aluminum lake and FD&C yellow
no. 6 aluminum lake. The 7.5 mg also contains: FD&C blue no.1 aluminum lake. The 10 mg also contains: FD&C red no. 40 aluminum lake. The 15 mg also contains: FD&C blue no. 2 aluminum lake and FD&C red no. 40 aluminum lake.
TrexallTM (methotrexate tablets, USP) (formerly Amethopterin) is an antimetabolite used in the treatment
of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. TrexallTM (methotrexate tablets) are indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy, but only when the diagnosis has been established, as by biopsy and/or after dermatologic consultation. It is important to ensure that a psoriasis "flare" is not due to an undiagnosed concomitant disease affecting immune responses.
Directions: 1.Weekly single oral, IM or IV dose schedule: 10 to 25 mg per week until adequate response is achieved.
2.Divided oral dose schedule: 2.5 mg at 12-hour intervals for three doses.
Dosages in each schedule may be gradually adjusted to achieve optimal clinical response; 30 mg/week
should not ordinarily be exceeded.
Once optimal clinical response has been achieved, each dosage schedule should be reduced to the lowest
possible amount of drug and to the longest possible rest period.
